Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM102413
Substrate
n/a
Meas. Tech.
Binding Assay
Temperature
298.15±0 K
Ki
6.85±0.0 nM
Citation
 Inagaki, M; Hara, S; Haga, N; Tamura, Y; Goto, Y; Hasegawa, T 6,7-unsaturated-7-carbamoyl substituted morphinan derivative US Patent  US8536192 Publication Date 9/17/2013 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM102413
Synonyms:
US8536192, I-240
Type:
Small organic molecule
Emp. Form.:
C31H31N3O6
Mol. Mass.:
541.5943
SMILES:
Cc1cc(=O)[nH]c2cc(NC(=O)C3C[C@@]4(O)[C@H]5Cc6ccc(O)c7O[C@@H](C3=O)[C@]4(CCN5CC3CC3)c67)ccc12 |r,TLB:13:14:36.18.17:29.31.30,THB:15:14:36.18.17:29.31.30|
Structure:
Search PDB for entries with ligand similarity: