Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM50332292
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
0.074±0.0 nM
IC50
117±0.0 nM
Citation
Kozlowski, JA; Yu, W; Wong, MK; Kim, SH; Tong, L; Lavey, BJ; Shankar, BB; Yang, D; Feltz, R; Kosinski, AM; Zhou, G; Rizvi, RK; Dai, C; Fire, L; Girijavallabhan, V; Li, D; Popovici-Muller, J; Richard, JE; Rosner, KE; Siddiqui, MA; Yang, L Compounds for the treatment of inflammatory disorders US Patent US8541572 Publication Date 9/24/2013
More Info.:
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
Inhibitor
Name:
BDBM50332292
Synonyms:
(R)-5-((4-(3-hydroxypyridin-2-yl)phenyl)ethynyl)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)imidazolidine-2,4-dione | CHEMBL1288000 | US8541572, 934
Type:
Small organic molecule
Emp. Form.:
C26H20N4O5
Mol. Mass.:
468.4608
SMILES:
COc1ccc2CN(C[C@]3(NC(=O)NC3=O)C#Cc3ccc(cc3)-c3ncccc3O)C(=O)c2c1 |r|