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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM102929
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
53±0.0 nM
Citation
 Mazurov, AA; Miao, L 3-substituted-2-(arlyalkyl)-1-azabicycloalkanes and methods of use thereof US Patent  US8541447 Publication Date 9/24/2013 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM102929
Synonyms:
US8541447, 5
Type:
Small organic molecule
Emp. Form.:
C20H22N2OS
Mol. Mass.:
338.466
SMILES:
O=C(NC1CN2CCC1CC2)c1ccc(Sc2ccccc2)cc1 |(-2,-1.92,;-2,-.38,;-3.33,.39,;-4.67,-.38,;-4.67,-1.93,;-6,-2.7,;-7.34,-1.93,;-7.34,-.38,;-6,.39,;-5.23,-.95,;-6.72,-1.35,;-.67,.39,;.67,-.38,;2,.39,;2,1.93,;3.33,2.7,;4.67,1.93,;4.67,.39,;6,-.38,;7.34,.39,;7.34,1.93,;6,2.7,;.67,2.69,;-.67,1.93,)|
Structure:
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