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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM102931
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
5±0.0 nM
Citation
 Mazurov, AA; Miao, L 3-substituted-2-(arlyalkyl)-1-azabicycloalkanes and methods of use thereof US Patent  US8541447 Publication Date 9/24/2013 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM102931
Synonyms:
US8541447, 7
Type:
Small organic molecule
Emp. Form.:
C20H22BrN3O2
Mol. Mass.:
416.312
SMILES:
Brc1ccc(NC(=O)OC2C3CCN(CC3)C2Cc2cccnc2)cc1 |(6,.77,;4.67,1.54,;3.33,.77,;2,1.54,;2,3.08,;.67,3.85,;-.67,3.08,;-.67,1.54,;-2,3.85,;-3.33,3.08,;-4.67,3.85,;-6,3.08,;-6,1.54,;-4.67,.77,;-5.39,2.12,;-3.9,2.52,;-3.33,1.54,;-2,.77,;-2,-.77,;-3.33,-1.54,;-3.33,-3.08,;-2,-3.85,;-.67,-3.08,;-.67,-1.54,;3.33,3.85,;4.67,3.08,)|
Structure:
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