Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM104696
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
2.0±0.0 nM
Citation
 Breslin, MJ; Coleman, PJ; Cox, CD; Schreier, JD Pyridyl piperidine orexin receptor antagonists US Patent  US8569311 Publication Date 10/29/2013 
Target
Name:
Orexin receptor type 2
Synonyms:
Hcrtr2 | Hypocretin receptor type 2 | OX2R_RAT | Orexin receptor 2 | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Ox-2-R | Ox2-R | Ox2R
Type:
Protein
Mol. Mass.:
52508.46
Organism:
Rattus norvegicus (Rat)
Description:
P56719
Residue:
460
Sequence:
MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
  
Inhibitor
Name:
BDBM104696
Synonyms:
US8569311, I-7
Type:
Small organic molecule
Emp. Form.:
C24H25FN4O3
Mol. Mass.:
436.4787
SMILES:
C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(CO)ccc1-c1ncccn1 |r|
Structure:
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