Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM106453
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
609.5±0.0 nM
Citation
 Gobbi, L; Rodriguez Sarmiento, RM; Wichmann, J Anellated pyridine compounds US Patent  US8586579 Publication Date 11/19/2013 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM106453
Synonyms:
US8586579, 42
Type:
Small organic molecule
Emp. Form.:
C24H36N4O3
Mol. Mass.:
428.5676
SMILES:
O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nccc3OCCc23)CC1)C1CCOC1 |r,wU:3.2,wD:6.6,(5.75,-.82,;6.52,.52,;5.75,1.85,;4.21,1.85,;3.44,.52,;1.9,.52,;1.13,1.85,;-.41,1.85,;-1.18,.52,;-2.72,.52,;-3.49,-.82,;-5.03,-.82,;-5.8,.52,;-5.03,1.85,;-3.49,1.85,;-7.34,.52,;-8.12,1.85,;-9.65,1.85,;-10.43,.52,;-9.65,-.82,;-10.13,-2.28,;-8.89,-3.19,;-7.64,-2.28,;-8.12,-.82,;1.9,3.19,;3.44,3.19,;8.06,.52,;8.96,1.76,;10.43,1.29,;10.43,-.25,;8.96,-.73,)|
Structure:
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