Reaction Details
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Probable G-protein coupled receptor 160
Ligand
BDBM281680
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
550±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281680
Synonyms:
US10023519, Example 21
Type:
Small organic molecule
Emp. Form.:
C21H19FN2O4
Mol. Mass.:
382.385
SMILES:
Cc1nc(no1)-c1ccc(F)c(c1)-c1ccc(cc1)[C@@H]1C[C@@H](C1)OCC(O)=O |r,wD:19.21,21.26,(-11.28,-2.96,;-9.87,-2.33,;-9.55,-.83,;-8.02,-.67,;-7.39,-2.07,;-8.54,-3.1,;-7.25,.67,;-8.02,2,;-7.25,3.33,;-5.71,3.33,;-4.94,4.67,;-4.94,2,;-5.71,.67,;-3.4,2,;-2.63,.67,;-1.09,.67,;-.32,2,;-1.09,3.33,;-2.63,3.33,;1.22,2,;2.31,3.09,;3.4,2,;2.31,.91,;4.94,2,;5.71,3.33,;7.25,3.33,;8.02,2,;8.02,4.67,)|
Structure:
