Reaction Details
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Probable G-protein coupled receptor 160
Ligand
BDBM281683
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
2900±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281683
Synonyms:
Cis-2-(3-(4-(5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)phenyl)cyclobutoxy) acetic acid | US10023519, Example 24
Type:
Small organic molecule
Emp. Form.:
C22H23ClO4
Mol. Mass.:
386.869
SMILES:
CC1(C)Cc2cc(Cl)cc(c2O1)-c1ccc(cc1)C1C[C@@H](C1)OCC(O)=O |r,wD:20.25,(-7.25,3.85,;-6.48,2.52,;-5.71,3.85,;-7.72,1.61,;-7.25,.15,;-8.02,-1.18,;-7.25,-2.52,;-8.02,-3.85,;-5.71,-2.52,;-4.94,-1.18,;-5.71,.15,;-5.23,1.61,;-3.4,-1.18,;-2.63,-2.52,;-1.09,-2.52,;-.32,-1.18,;-1.09,.15,;-2.63,.15,;1.22,-1.18,;2.31,-.1,;3.4,-1.18,;2.31,-2.27,;4.94,-1.18,;5.71,.15,;7.25,.15,;8.02,-1.18,;8.02,1.48,)|
Structure:
