Reaction Details
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Probable G-protein coupled receptor 160
Ligand
BDBM281695
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
130±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281695
Synonyms:
US10023519, Example 36
Type:
Small organic molecule
Emp. Form.:
C24H19F3O4
Mol. Mass.:
428.4005
SMILES:
OC(=O)CO[C@H]1C[C@H](C1)c1ccc(cc1)-c1cc(Oc2cccc(F)c2)cc(F)c1F |r,wD:7.9,5.4,(8.02,2.67,;7.25,4,;8.02,5.33,;5.71,4,;4.94,2.67,;3.4,2.67,;2.31,3.76,;1.22,2.67,;2.31,1.58,;-.32,2.67,;-1.09,1.33,;-2.63,1.33,;-3.4,2.67,;-2.63,4,;-1.09,4,;-4.94,2.67,;-5.71,1.33,;-7.25,1.33,;-8.02,,;-7.25,-1.33,;-8.02,-2.67,;-7.25,-4,;-5.71,-4,;-4.94,-2.67,;-3.4,-2.67,;-5.71,-1.33,;-8.02,2.67,;-7.25,4,;-8.02,5.33,;-5.71,4,;-4.94,5.33,)|
Structure:
