Reaction Details
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Probable G-protein coupled receptor 160
Ligand
BDBM281701
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
2210±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281701
Synonyms:
US10023519, Example 42
Type:
Small organic molecule
Emp. Form.:
C22H23FO3
Mol. Mass.:
354.4146
SMILES:
CC(C)Oc1ccc(F)c(c1)-c1ccc(cc1)C1CC2(C[C@@H]2C(O)=O)C1 |r,wU:21.24,(-7.63,-9.49,;-6.86,-8.15,;-5.32,-8.15,;-7.63,-6.82,;-6.86,-5.49,;-7.63,-4.15,;-6.86,-2.82,;-5.32,-2.82,;-4.55,-1.49,;-4.55,-4.15,;-5.32,-5.49,;-3.01,-4.15,;-2.24,-5.49,;-.7,-5.49,;.07,-4.15,;-.7,-2.82,;-2.24,-2.82,;1.61,-4.15,;2.69,-5.24,;3.78,-4.15,;5.12,-4.92,;5.12,-3.38,;5.74,-1.98,;4.84,-.73,;7.28,-1.81,;2.69,-3.06,)|
Structure:
