Reaction Details
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Probable G-protein coupled receptor 160
Ligand
BDBM281708
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
500±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281708
Synonyms:
3-((2′-Fluoro-5′-isopropoxy-[1,1′-biphenyl]-4-yl)methyl)cyclobutanecarboxylic acid | US10023519, Example 49
Type:
Small organic molecule
Emp. Form.:
C21H23FO3
Mol. Mass.:
342.4039
SMILES:
CC(C)Oc1ccc(F)c(c1)-c1ccc(C[C@H]2C[C@H](C2)C(O)=O)cc1 |r,wD:16.16,18.21,(-4.39,-12.03,;-5.93,-12.03,;-6.7,-13.36,;-6.7,-10.69,;-5.93,-9.36,;-6.7,-8.03,;-5.93,-6.69,;-4.39,-6.69,;-3.62,-5.36,;-3.62,-8.03,;-4.39,-9.36,;-2.08,-8.03,;-1.31,-9.36,;.23,-9.36,;1,-8.03,;2.54,-8.03,;3.31,-6.69,;4.79,-6.29,;4.39,-4.81,;2.91,-5.21,;5.16,-3.47,;6.7,-3.47,;4.39,-2.14,;.23,-6.69,;-1.31,-6.69,)|
Structure:
