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Target
D(2) dopamine receptor
Ligand
BDBM107512
Substrate
n/a
Meas. Tech.
Biochemical Assay
Ki
133.46±0.0 nM
Citation
 Rodriguez Sarmiento, RM; Wichmann, J Benzodioxole piperidine compounds US Patent  US8598357 Publication Date 12/3/2013 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM107512
Synonyms:
US8598357, 15
Type:
Small organic molecule
Emp. Form.:
C27H35N3O3
Mol. Mass.:
449.5851
SMILES:
Cc1ccc(cn1)C(=O)N[C@H]1CC[C@H](CCN2CCC(CC2)c2cccc3OCOc23)CC1 |r,wU:10.10,wD:13.14,(11.55,.52,;10.01,.52,;9.24,1.85,;7.7,1.85,;6.93,.52,;7.7,-.82,;9.24,-.82,;5.39,.52,;4.62,-.82,;4.62,1.85,;3.08,1.85,;2.31,.52,;.77,.52,;,1.85,;-1.54,1.85,;-2.31,.52,;-3.85,.52,;-4.62,-.82,;-6.16,-.82,;-6.93,.52,;-6.16,1.85,;-4.62,1.85,;-8.47,.52,;-9.24,1.85,;-10.78,1.85,;-11.55,.52,;-10.78,-.82,;-11.26,-2.28,;-10.01,-3.19,;-8.76,-2.28,;-9.24,-.82,;.77,3.19,;2.31,3.19,)|
Structure:
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