Reaction Details Report a problem with these data
Target
Secreted chorismate mutase
Ligand
BDBM108072
Substrate
n/a
Meas. Tech.
CM Assay
Temperature
310.15±n/a K
IC50
2.500e+4± 3.40e+3 nM
Comments
extracted
Citation
 Jeankumar, VU; Alokam, R; Sridevi, JP; Suryadevara, P; Matikonda, SS; Peddi, S; Sahithi, S; Alvala, M; Yogeeswari, P; Sriram, D Discovery and Structure Optimization of a Series of Isatin Derivatives as Mycobacterium tuberculosis Chorismate Mutase Inhibitors. Chem Biol Drug Des 83:498-506 (2014) [PubMed]  Article 
Target
Name:
Secreted chorismate mutase
Synonyms:
Chorismate mutase (CM) | Chorismate mutase (MTB CM) | Chorismate mutase-related protein | SCMU_MYCTU
Type:
Protein
Mol. Mass.:
21942.03
Organism:
Mycobacterium tuberculosis H37Rv
Description:
n/a
Residue:
199
Sequence:
MLTRPREIYLATAVSIGILLSLIAPLGPPLARADGTSQLAELVDAAAERLEVADPVAAFKWRAQLPIEDSGRVEQQLAKLGEDARSQHIDPDYVTRVFDDQIRATEAIEYSRFSDWKLNPASAPPEPPDLSASRSAIDSLNNRMLSQIWSHWSLLSAPSCAAQLDRAKRDIVRSRHLDSLYQRALTTATQSYCQALPPA
  
Inhibitor
Name:
BDBM108072
Synonyms:
1‐[(3Z)‐1‐acetyl‐2‐oxoindol‐3‐ylidene]‐3‐aminourea (Compound 12)
Type:
Small organic molecule
Emp. Form.:
C11H10N4O3
Mol. Mass.:
246.2221
SMILES:
CC(=O)N1C(=O)C(=NC(=O)NN)c2ccccc12 |w:7.7|
Structure:
Search PDB for entries with ligand similarity: