Reaction Details Report a problem with these data
Target
Secreted chorismate mutase
Ligand
BDBM108073
Substrate
n/a
Meas. Tech.
CM Assay
Temperature
310.15±n/a K
IC50
>1.00e+5±n/a nM
Comments
extracted
Citation
 Jeankumar, VU; Alokam, R; Sridevi, JP; Suryadevara, P; Matikonda, SS; Peddi, S; Sahithi, S; Alvala, M; Yogeeswari, P; Sriram, D Discovery and Structure Optimization of a Series of Isatin Derivatives as Mycobacterium tuberculosis Chorismate Mutase Inhibitors. Chem Biol Drug Des 83:498-506 (2014) [PubMed]  Article 
Target
Name:
Secreted chorismate mutase
Synonyms:
Chorismate mutase (CM) | Chorismate mutase (MTB CM) | Chorismate mutase-related protein | SCMU_MYCTU
Type:
Protein
Mol. Mass.:
21942.03
Organism:
Mycobacterium tuberculosis H37Rv
Description:
n/a
Residue:
199
Sequence:
MLTRPREIYLATAVSIGILLSLIAPLGPPLARADGTSQLAELVDAAAERLEVADPVAAFKWRAQLPIEDSGRVEQQLAKLGEDARSQHIDPDYVTRVFDDQIRATEAIEYSRFSDWKLNPASAPPEPPDLSASRSAIDSLNNRMLSQIWSHWSLLSAPSCAAQLDRAKRDIVRSRHLDSLYQRALTTATQSYCQALPPA
  
Inhibitor
Name:
BDBM108073
Synonyms:
(3Z)‐3‐[(5‐nitro‐1,3‐thiazol‐2‐yl)imino]‐1H‐indol‐2‐ one (Compound 13)
Type:
Small organic molecule
Emp. Form.:
C11H6N4O3S
Mol. Mass.:
274.255
SMILES:
[O-][N+](=O)c1cnc(\N=C2/C(=O)Nc3ccccc23)s1
Structure:
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