Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50047157
Substrate
n/a
Ki
125±24.2 nM
Citation
 Van der Walt, MM; Terre'Blanche, G; Petzer, A; Lourens, AC; Petzer, JP The adenosine A(2A) antagonistic properties of selected C8-substituted xanthines. Bioorg Chem 49:49-58 (2013) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_RAT | ADENOSINE A2a | Adenosine A2 receptor | Adenosine A2a receptor (A2a) | Adenosine Receptors A2a (A2a) | Adenosine receptor A2a and A3 | Adenosine receptors A2a | Adora2a | Rat striatal adenosine A2a receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45015.65
Organism:
Rattus norvegicus (rat)
Description:
Rat A2A receptors expressed in CHO cells.
Residue:
410
Sequence:
MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
  
Inhibitor
Name:
BDBM50047157
Synonyms:
(E)-8-[3-(Trifluoromethyl)styryl]-1,3,7-trimethylxanthine (4e) | 1,3,7-Trimethyl-8-[2-(3-trifluoromethyl-phenyl)-vinyl]-3,7-dihydro-purine-2,6-dione | CHEMBL28267
Type:
Small organic molecule
Emp. Form.:
C17H15F3N4O2
Mol. Mass.:
364.3218
SMILES:
Cn1c(\C=C\c2cccc(c2)C(F)(F)F)nc2n(C)c(=O)n(C)c(=O)c12
Structure:
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