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Target
Tyrosine-protein kinase CSK
Ligand
BDBM110215
Substrate
n/a
Meas. Tech.
c-Src Kinase Inhibitory Activity Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
2.01e+4±n/a nM
Comments
extracted
Citation
 Chand, K; Prasad, S; Tiwari, RK; Shirazi, AN; Kumar, S; Parang, K; Sharma, SK Synthesis and evaluation of c-Src kinase inhibitory activity of pyridin-2(1H)-one derivatives. Bioorg Chem 53:75-82 (2014) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase CSK
Synonyms:
C-SRC kinase | C-src tyrosine kinase | CSK | CSK_HUMAN | Protein-tyrosine kinase CYL | Tyrosine Kinase CSK
Type:
Tyrosine-protein kinase
Mol. Mass.:
50707.30
Organism:
Homo sapiens (Human)
Description:
P41240
Residue:
450
Sequence:
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
  
Inhibitor
Name:
BDBM110215
Synonyms:
(E)-1-Cyclohexyl-5-[(cyclohexylimino)(2-hydroxyphenyl) methyl]pyridin-2(1H)-one (45)
Type:
Small organic molecule
Emp. Form.:
C24H30N2O2
Mol. Mass.:
378.5072
SMILES:
Oc1ccccc1\C(=N\C1CCCCC1)c1ccc(=O)n(c1)C1CCCCC1
Structure:
Search PDB for entries with ligand similarity: