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Target
Lipoxygenase
Ligand
BDBM111816
Substrate
n/a
Meas. Tech.
Lipo-oxygenase activity assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
6.376e+4± 1.84e+3 nM
Comments
extracted
Citation
 Ahmad, W; Kumolosasi, E; Jantan, I; Bukhari, SN; Jasamai, M Effects of novel diarylpentanoid analogues of curcumin on secretory phospholipase A2 , cyclooxygenases, lipo-oxygenase, and microsomal prostaglandin E synthase-1. Chem Biol Drug Des 83:670-81 (2014) [PubMed]  Article 
Target
Name:
Lipoxygenase
Synonyms:
Lipoxygenase (LOX)
Type:
Protein
Mol. Mass.:
96302.37
Organism:
Glycine max (Soybean)
Description:
n/a
Residue:
859
Sequence:
MTGGMFGRKGQKIKGTVVLMPKNVLDFNAITSVGKGSAKDTATDFLGKGLDALGHAVDALTAFAGHSISLQLISATQTDGSGKGKVGNEAYLEKHLPTLPTLGARQEAFDINFEWDASFGIPGAFYIKNFMTDEFFLVSVKLEDIPNHGTINFVCNSWVYNFKSYKKNRIFFVNDTYLPSATPGPLVKYRQEELEVLRGDGTGKRRDFDRIYDYDIYNDLGNPDGGDPRPIIGGSSNYPYPRRVRTGREKTRKDPNSEKPGEIYVPRDENFGHLKSSDFLTYGIKSLSQNVIPLFKSIILNLRVTSSEFDSFDEVRGLFEGGIKLPTNILSQISPLPVLKEIFRTDGENTLQFPPPHVIRVSKSGWMTDDEFAREMIAGVNPNVIRRLQEFPPKSTLDPATYGDQTSTITKQQLEINLGGVTVEEAISAHRLFILDYHDAFFPYLTKINSLPIAKAYATRTILFLKDDGSLKPLAIELSKPATVSKVVLPATEGVESTIWLLAKAHVIVNDSGYHQLISHWLNTHAVMEPFAIATNRHLSVLHPIYKLLYPHYKDTININGLARQSLINAGGIIEQTFLPGKYSIEMSSVVYKNWVFTDQALPADLVKRGLAVEDPSAPHGLRLVIEDYPYAVDGLEIWDAIKTWVHEYVSVYYPTNAAIQQDTELQAWWKEVVEKGHGDLKDKPWWPKLQTVEDLIQSCSIIIWTASALHAAVNFGQYPYGGYIVNRPTLARRFIPEEGTKEYDEMVKDPQKAYLRTITPKFETLIDISVIEILSRHASDEVYLGQRDNPNWTTDSKALEAFKKFGNKLAEIEGKITQRNNDPSLKSRHGPVQLPYTLLHRSSEEGMSFKGIPNSISI
  
Inhibitor
Name:
BDBM111816
Synonyms:
(2E,5E)‐2,5‐bis[(2,3‐ dimethoxyphenyl)methylidene]cyclopentan‐1‐one (15)
Type:
Small organic molecule
Emp. Form.:
C23H24O5
Mol. Mass.:
380.4337
SMILES:
COc1cccc(\C=C2/CC\C(=C/c3cccc(OC)c3OC)C2=O)c1OC
Structure:
Search PDB for entries with ligand similarity: