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Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Ligand
BDBM112624
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
6.5±0
IC50
5e+3±n/a nM
Citation
 Gerusz, V; Escaich, S; Oxoby, M; Moreau, F Acylpiperazinones and their use as pharmaceuticals US Patent  US8623865 Publication Date 1/7/2014 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | Enoyl-acyl carrier protein reductase (FaBI) | FABI_STAA8 | NADPH-dependent enoyl-ACP reductase (FabI) | fabI
Type:
Enzyme
Mol. Mass.:
28019.03
Organism:
Staphylococcus aureus
Description:
Q2FZQ3
Residue:
256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISASPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK
  
Inhibitor
Name:
BDBM112624
Synonyms:
US8623865, 3
Type:
Small organic molecule
Emp. Form.:
C21H20F2N2O6
Mol. Mass.:
434.3901
SMILES:
CCc1cc(OC(=O)OC)c(Oc2ccc(cc2F)C(=O)N2CCNC(=O)C2)cc1F
Structure:
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