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Target
Tyrosyl-DNA phosphodiesterase 2
Ligand
BDBM53457
Substrate
n/a
Meas. Tech.
Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2)
IC50
128357±n/a nM
Citation
 PubChem, PC Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) PubChem Bioassay (2014)[AID] 
Target
Name:
Tyrosyl-DNA phosphodiesterase 2
Synonyms:
EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40916.54
Organism:
Homo sapiens (Human)
Description:
gi_23510348
Residue:
362
Sequence:
MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNSYFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQLKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQMNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDIIL
  
Inhibitor
Name:
BDBM53457
Synonyms:
2,4-bis(bromanyl)-6-[(quinolin-8-ylamino)methyl]phenol | 2,4-dibromo-6-[(8-quinolinylamino)methyl]phenol | 2,4-dibromo-6-[(8-quinolylamino)methyl]phenol | 2,4-dibromo-6-[(quinolin-8-ylamino)methyl]phenol | MLS001183429 | O-acyl oxime isatin derivative, 40 | SMR000503121 | cid_1994749
Type:
Small organic molecule
Emp. Form.:
C16H12Br2N2O
Mol. Mass.:
408.087
SMILES:
Oc1c(Br)cc(Br)cc1CNc1cccc2cccnc12
Structure:
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