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Target
Fibrinogen beta chain [164-491]
Ligand
BDBM32108
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer
IC50
83293±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] PubChem Bioassay (2013)[AID] 
Target
Name:
Fibrinogen beta chain [164-491]
Synonyms:
Chain E, Fragment Double-D From Human Fibrin | FGB | FIBB_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37647.12
Organism:
Homo sapiens (Human)
Description:
gi_28373962
Residue:
328
Sequence:
DNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
  
Inhibitor
Name:
BDBM32108
Synonyms:
6-keto-7,8,9,10-tetrahydrophenothiazine-3-carboxylic acid methyl ester | 6-oxo-7,8,9,10-tetrahydrophenothiazine-3-carboxylic acid methyl ester | MLS000100349 | SMR000082651 | cid_1258835 | methyl 4-oxo-2,3,4,10-tetrahydro-1H-phenothiazine-7-carboxylate | methyl 6-oxidanylidene-7,8,9,10-tetrahydrophenothiazine-3-carboxylate | methyl 6-oxo-7,8,9,10-tetrahydrophenothiazine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C14H13NO3S
Mol. Mass.:
275.323
SMILES:
COC(=O)c1ccc2N=C3CCCC(=O)C3Sc2c1 |t:8|
Structure:
Search PDB for entries with ligand similarity: