Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM51792
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR)
EC50
67554±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR) PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM51792
Synonyms:
MLS000072836 | N'-cyclopentyl-N'-[2-(cyclopentylamino)-2-keto-ethyl]-N-(2-pyridyl)glutaramide | N'-cyclopentyl-N'-[2-(cyclopentylamino)-2-oxidanylidene-ethyl]-N-pyridin-2-yl-pentanediamide | N'-cyclopentyl-N'-[2-(cyclopentylamino)-2-oxoethyl]-N-(2-pyridinyl)pentanediamide | N'-cyclopentyl-N'-[2-(cyclopentylamino)-2-oxoethyl]-N-pyridin-2-ylpentanediamide | Pentanedioic acid cyclopentyl-cyclopentylcarbamoylmethyl-amide pyridin-2-ylamide | SMR000004293 | cid_650348
Type:
Small organic molecule
Emp. Form.:
C22H32N4O3
Mol. Mass.:
400.5145
SMILES:
O=C(CCCC(=O)N(CC(=O)NC1CCCC1)C1CCCC1)Nc1ccccn1
Structure:
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