Reaction Details Report a problem with these data
Target
PC4 and SFRS1-interacting protein
Ligand
BDBM115149
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration
IC50
4485±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration PubChem Bioassay (2014)[AID] 
Target
Name:
PC4 and SFRS1-interacting protein
Synonyms:
DFS70 | LEDGF | LEDGF/p75 | PSIP1 | PSIP1_HUMAN | PSIP2 | lens epithelium-derived growth factor p75
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60120.68
Organism:
Homo sapiens (Human)
Description:
gi_6708281
Residue:
530
Sequence:
MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
  
Inhibitor
Name:
BDBM115149
Synonyms:
2-Naphthalenesulfonic acid, 6-(dimethylamino)-4-hydroxy- | 6-(dimethylamino)-4-hydroxy-2-naphthalenesulfonic acid | 6-(dimethylamino)-4-hydroxy-naphthalene-2-sulfonic acid | 6-(dimethylamino)-4-hydroxynaphthalene-2-sulfonic acid | 6-(dimethylamino)-4-oxidanyl-naphthalene-2-sulfonic acid | MLS002638055 | SMR001547551 | cid_80417
Type:
Small organic molecule
Emp. Form.:
C12H13NO4S
Mol. Mass.:
267.301
SMILES:
CN(C)c1ccc2cc(cc(O)c2c1)S(O)(=O)=O
Structure:
Search PDB for entries with ligand similarity: