Reaction Details Report a problem with these data
Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM50378639
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
IC50
66.4±n/a nM
Comments
extracted
Citation
 Cho, H; Wu, Y; Choi, C Thiazolidinedione derivative and use thereof US Patent  US8637558 Publication Date 1/28/2014 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM50378639
Synonyms:
CHEMBL599018 | US8637558, 37
Type:
Small organic molecule
Emp. Form.:
C18H21NO3S
Mol. Mass.:
331.429
SMILES:
CC1CCC(COc2ccc(C=C3SC(O)=NC3=O)cc2)CC1 |w:11.10,c:15,(4.23,-1.81,;3.51,-1.4,;3.51,-.57,;2.8,-.16,;2.08,-.57,;1.37,-.16,;.65,-.57,;-.06,-.16,;-.06,.67,;-.78,1.08,;-1.49,.67,;-2.2,1.08,;-2.92,.67,;-3.01,-.15,;-3.81,-.33,;-4.15,-1.08,;-4.23,.39,;-3.67,1,;-3.84,1.81,;-1.49,-.16,;-.78,-.57,;2.08,-1.4,;2.8,-1.81,)|
Structure:
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