Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM118172
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
4.1±n/a nM
Comments
extracted
Citation
 Yoshida, H; Tonogaki, K; Sakagami, M; Takaya, K Cyclohexane derivative having NPY Y5 receptor antagonism US Patent  US8653125 Publication Date 2/18/2014 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_MOUSE | Neuropeptide Y receptor Y5 | Neuropeptide Y receptor type 5 (NPY Y5) | Npy5 | Npy5r
Type:
Enzyme
Mol. Mass.:
52807.91
Organism:
Mus musculus (Mouse)
Description:
O70342
Residue:
466
Sequence:
MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM118172
Synonyms:
US8653125, Ia-14
Type:
Small organic molecule
Emp. Form.:
C26H25FN2O2
Mol. Mass.:
416.4873
SMILES:
Fc1ccccc1-c1cccc(NC(=O)[C@@H]2CC[C@@H](CC2)NC(=O)c2ccccc2)c1 |r,wU:18.22,15.15,(8.67,-3.08,;8.67,-1.54,;10,-.77,;10,.77,;8.67,1.54,;7.34,.77,;7.34,-.77,;6,-1.54,;6,-3.08,;4.67,-3.85,;3.33,-3.08,;3.33,-1.54,;2,-.77,;.67,-1.54,;.67,-3.08,;-.67,-.77,;-.67,.77,;-2,1.54,;-3.33,.77,;-3.33,-.77,;-2,-1.54,;-4.67,1.54,;-6,.77,;-6,-.77,;-7.34,1.54,;-8.67,.77,;-10,1.54,;-10,3.08,;-8.67,3.85,;-7.34,3.08,;4.67,-.77,)|
Structure:
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