Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM118187
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
1.1±n/a nM
Comments
extracted
Citation
 Yoshida, H; Tonogaki, K; Sakagami, M; Takaya, K Cyclohexane derivative having NPY Y5 receptor antagonism US Patent  US8653125 Publication Date 2/18/2014 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_MOUSE | Neuropeptide Y receptor Y5 | Neuropeptide Y receptor type 5 (NPY Y5) | Npy5 | Npy5r
Type:
Enzyme
Mol. Mass.:
52807.91
Organism:
Mus musculus (Mouse)
Description:
O70342
Residue:
466
Sequence:
MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM118187
Synonyms:
US8653125, Ic-12
Type:
Small organic molecule
Emp. Form.:
C26H30ClN3O3
Mol. Mass.:
467.988
SMILES:
C[C@H]1CN(C[C@@H](C)O1)c1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)Oc2cc(Cl)ccc2C#N)cc1 |r,wU:18.22,15.15,1.0,5.5,(7.34,-6.16,;7.34,-4.62,;6,-3.85,;6,-2.31,;7.34,-1.54,;8.67,-2.31,;10,-1.54,;8.67,-3.85,;4.67,-1.54,;3.33,-2.31,;2,-1.54,;2,,;.67,.77,;-.67,,;-.67,-1.54,;-2,.77,;-2,2.31,;-3.33,3.08,;-4.67,2.31,;-4.67,.77,;-3.33,,;-6,3.08,;-7.34,2.31,;-7.34,.77,;-8.67,,;-8.67,-1.54,;-10,.77,;-10,2.31,;-8.67,3.08,;-8.67,4.62,;-8.67,6.16,;3.33,.77,;4.67,,)|
Structure:
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