Reaction Details Report a problem with these data
Target
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
Ligand
BDBM119123
Substrate
n/a
IC50
6e+3±n/a nM
Citation
 Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem 55:2-15 (2014) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
Synonyms:
MURE_STAA8 | MurE (S. aureus) | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | murE
Type:
Protein
Mol. Mass.:
54095.36
Organism:
Staphylococcus aureus
Description:
Q2FZP6
Residue:
493
Sequence:
MDASTLFKKVKVKRVLGSLEQQIDDITTDSRTAREGSIFVASVGYTVDSHKFCQNVADQGCKLVVVNKEQSLPANVTQVVVPDTLRVASILAHTLYDYPSHQLVTFGVTGTNGKTSIATMIHLIQRKLQKNSAYLGTNGFQINETKTKGANTTPETVSLTKKIKEAVDAGAESMTLEVSSHGLVLGRLRGVEFDVAIFSNLTQDHLDFHGTMEAYGHAKSLLFSQLGEDLSKEKYVVLNNDDSFSEYLRTVTPYEVFSYGIDEEAQFMAKNIQESLQGVSFDFVTPFGTYPVKSPYVGKFNISNIMAAMIAVWSKGTSLETIIKAVENLEPVEGRLEVLDPSLPIDLIIDYAHTADGMNKLIDAVQPFVKQKLIFLVGMAGERDLTKTPEMGRVACRADYVIFTPDNPANDDPKMLTAELAKGATHQNYIEFDDRAEGIKHAIDIAEPGDTVVLASKGREPYQIMPGHIKVPHRDDLIGLEAAYKKFGGGPVD
  
Inhibitor
Name:
BDBM119123
Synonyms:
MurD/E/F inhibitor (compound 69)
Type:
Small organic molecule
Emp. Form.:
C10H7NO4S2
Mol. Mass.:
269.297
SMILES:
Oc1ccc(C=C2SC(S)=NC2=O)c(O)c1O |w:5.4,c:9|
Structure:
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