Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM92602
Substrate
n/a
Meas. Tech.
Enzymatic Assays
IC50
5600±n/a nM
Citation
 Bastos, C; Booker, ML; Celatka, CA; Clardy, JC; Cortese, J; Patel, VP; Skerlj, R; Wiegand, RC; Wirth, DF Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase US Patent  US8703811 Publication Date 4/22/2014 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial, putative
Type:
PROTEIN
Mol. Mass.:
62972.27
Organism:
Plasmodium vivax
Description:
A5K1N1
Residue:
572
Sequence:
MLRHSCLREKGNLIGGSLLRGISAQLRAAGGGTFRSFHSYRSFCSFCIFRRANKADANWYGCFPGHVAGGATCGPLRGDCAERHKLMAHVRRFSGESTRAKGGDKREGDIEGNRTNGSDKTKQLEEEMKKLNEQIAREKGNHKKALLFIFTCVVALYMYFESYDPEFFLYDVFLKMLLKYVDGETCHELFLLMGKYKLLPYDTGKDNIYSCSEIKGLNFINPFGVAAGFDKNGVCIDGILKLGFSFIEIGTITPKAQKGNERPRIFRDLETRSIINSCGFNNMGCDEVCKNLKRFRERQKTDKLLQRHLVGVSLGKNKDSPDILQDLSYCIGKIGRYADYIAINVSSPNTPGLRDHQKGERLHGIIQRVKEEVAKLDGGGAPLGGATTGGAAMGGATTGEAVVGKAPPDEAATGGEPWANTTKRRPLIFVKLAPDLEEGERKSIANVLLNAEVDGMIICNTTTQKFNIKSFEDKKGGVSGEKLKGVSTHMISQMYNYTNGKIPIIASGGIFTGEDALEKIEAGASVCQLYSCLVFNGMKAAVRIKRELDHLLYQRGYYKLGDAVGRAHRRAA
  
Inhibitor
Name:
BDBM92602
Synonyms:
DHOD Inhibitor, 1 | US8703811, 2
Type:
Small molecule
Emp. Form.:
C18H15NO
Mol. Mass.:
261.3178
SMILES:
Cc1ccccc1C=Cc1cc(O)c2ccccc2n1 |w:7.7|
Structure:
Search PDB for entries with ligand similarity: