Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 1 [89-488]
Ligand
BDBM120758
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
Temperature
277.15±n/a K
IC50
197±n/a nM
Comments
extracted
Citation
 Forster, CJ; Kwak, Y; Nakajima, K; Wang, B Organic compounds US Patent  US8703761 Publication Date 4/22/2014 
Target
Name:
Diacylglycerol O-acyltransferase 1 [89-488]
Synonyms:
AGRP1 | DGAT | DGAT1 | DGAT1_HUMAN | acyl coA-diacylglycerol acyl transferase 1 (DGAT1)
Type:
Protein
Mol. Mass.:
46366.89
Organism:
Homo sapiens (Human)
Description:
O75907[89-488]
Residue:
400
Sequence:
LNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM120758
Synonyms:
US8703761, 6-14
Type:
Small organic molecule
Emp. Form.:
C23H18F2N4O3S2
Mol. Mass.:
500.541
SMILES:
CC(C)(NC(=O)c1cncs1)C(=O)Nc1nc(c(Oc2ccc(F)cc2)s1)-c1ccc(F)cc1
Structure:
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