Target
Prokineticin receptor 1
Ligand
BDBM121321
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
Temperature
310.15±n/a K
Ki
5.5±n/a nM
Comments
extracted
Citation
 Zhou, QLi, JHuang, Q Prokineticin receptor antagonists and uses thereof US Patent  US8722896 Publication Date 5/13/2014 
Target
Name:
Prokineticin receptor 1
Synonyms:
Prokineticin receptor 1 (PRK1)
Type:
Enzyme
Mol. Mass.:
44908.29
Organism:
Cricetulus griseus (Chinese hamster)
Description:
G3HIE5
Residue:
399
Sequence:
MPPPAWMEPTVGALGENTTDTSTSFLSLVNARGAQAASFPFTLSYGDYDTALGEEEDVTKSWTFFAARIVIGMALVAIMLVCGVGNFIFITTLARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTAAGLIFLVWSVSILIAIPAAYFTTETVLVIVESQEKIFCGQIWPVDQQVYYRSYFLLVFGLEFVGPVVAMTLCYARVSRELWFKAVPGFQTEQIRRRLRCRRRTVLGLVCVLSAYVLCWAPFYGFTIVRDFFPSVFVKEKHYLTAFYVVECIAMSNSMINTLCFVSVRNNTSKYLKRILRLQWRASPSGSKASADLDLRTTGMPATEEVDCIGLK
  
Inhibitor
Name:
BDBM121321
Synonyms:
US8722896, (-)-(3R)-1-(Indol-7-ylmethyl)- N-(9-chloro-3,3-difluoro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpyrrolidine-3- carboxamide
Type:
Small organic molecule
Emp. Form.:
C28H32ClF2N3O3
Mol. Mass.:
532.022
SMILES:
CC(C)CN(Cc1cc(Cl)c2OCC(F)(F)COc2c1)C(=O)C1CCN(Cc2cccc3cc[nH]c23)C1
Structure:
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