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Target
Prolyl hydroxylase EGLN3
Ligand
BDBM107702
Substrate
n/a
Meas. Tech.
Mass Spectrometry Assay
Temperature
298.15±n/a K
IC50
560±n/a nM
Comments
extracted
Citation
 Kawamoto, RM; Wu, S; Evdokimov, AG; Greis, KD; Boyer, AS; Warshakoon, NC Prolyl hydroxylase inhibitors and method of use US Patent  US8722895 Publication Date 5/13/2014 
Target
Name:
Prolyl hydroxylase EGLN3
Synonyms:
EGLN3 | EGLN3_HUMAN | Egl nine homolog 3 (EGLIN3) | Egl nine homolog 3 (EGLN3)
Type:
Protein
Mol. Mass.:
27265.54
Organism:
Homo sapiens (Human)
Description:
Q9H6Z9
Residue:
239
Sequence:
MPLGHIMRLDLEKIALEYIVPCLHEVGFCYLDNFLGEVVGDCVLERVKQLHCTGALRDGQLAGPRAGVSKRHLRGDQITWIGGNEEGCEAISFLLSLIDRLVLYCGSRLGKYYVKERSKAMVACYPGNGTGYVRHVDNPNGDGRCITCIYYLNKNWDAKLHGGILRIFPEGKSFIADVEPIFDRLLFFWSDRRNPHEVQPSYATRYAMTVWYFDAEERAEAKKKFRNLTRKTESALTED
  
Inhibitor
Name:
BDBM107702
Synonyms:
US8598210, Table XV, 8 | US8722895, 8: {[5-(4-Cyanophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C15H11N3O4
Mol. Mass.:
297.2655
SMILES:
OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)[N+]#[C-]
Structure:
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