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Target
C-C chemokine receptor type 3
Ligand
BDBM123074
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
Ki
19.1±n/a nM
Citation
 Frank, M; Haeberle, H; Henry, M; Pachur, T; Santagostino, M; Stertz, U; Trebing, T; Werthmann, U Co-crystals and salts of CCR3-inhibitors US Patent  US8742115 Publication Date 6/3/2014 
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
  
Inhibitor
Name:
BDBM123074
Synonyms:
US8742115, 13
Type:
Small organic molecule
Emp. Form.:
C28H34ClN5O4
Mol. Mass.:
540.054
SMILES:
Cc1cc(CN2CCC(CC2)N2[C@H](CCC2=O)C(=O)Nc2cc(ccn2)C(=O)N2CCOCC2)ccc1Cl |r|
Structure:
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