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Target
Cyclin-T1
Ligand
BDBM126531
Substrate
n/a
Meas. Tech.
IMAP Assay
IC50
0.00017±n/a nM
Citation
 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent  US8778951 Publication Date 7/15/2014 
Target
Name:
Cyclin-T1
Synonyms:
CCNT1 | CCNT1_HUMAN | CycT | CycT1 | Cyclin T | Cyclin T1 | Cyclin-T
Type:
Enzyme Subunit
Mol. Mass.:
80712.40
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
726
Sequence:
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK
  
Inhibitor
Name:
BDBM126531
Synonyms:
US8778951, 342
Type:
Small organic molecule
Emp. Form.:
C26H34ClFN6O
Mol. Mass.:
501.039
SMILES:
CCCN[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1ccc(F)c(NCC2(CCOCC2)C#N)n1 |r,wU:7.10,wD:4.3,(6.97,2.45,;5.64,1.68,;4.3,2.45,;2.97,1.68,;1.63,2.45,;1.63,3.99,;.3,4.76,;-1.03,3.99,;-1.03,2.45,;.3,1.68,;-2.37,4.76,;-3.7,3.99,;-3.7,2.45,;-5.03,1.68,;-6.37,2.45,;-7.7,1.68,;-6.37,3.99,;-5.03,4.76,;-5.03,.14,;-6.37,-.63,;-6.37,-2.17,;-5.03,-2.94,;-5.03,-4.48,;-3.7,-2.17,;-2.37,-2.94,;-1.03,-2.17,;.3,-2.94,;.3,-4.48,;1.63,-5.25,;2.97,-4.48,;2.97,-2.94,;1.63,-2.17,;.3,-1.4,;.3,.14,;-3.7,-.63,)|
Structure:
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