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Target
Cyclin-T1
Ligand
BDBM126547
Substrate
n/a
Meas. Tech.
IMAP Assay
IC50
0.00017±n/a nM
Citation
 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent  US8778951 Publication Date 7/15/2014 
Target
Name:
Cyclin-T1
Synonyms:
CCNT1 | CCNT1_HUMAN | CycT | CycT1 | Cyclin T | Cyclin T1 | Cyclin-T
Type:
Enzyme Subunit
Mol. Mass.:
80712.40
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
726
Sequence:
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK
  
Inhibitor
Name:
BDBM126547
Synonyms:
US8778951, 358
Type:
Small organic molecule
Emp. Form.:
C27H37ClN6O2
Mol. Mass.:
513.075
SMILES:
COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1 |r,wU:9.12,wD:6.5,3.3,(8,1.93,;6.67,2.7,;5.33,1.93,;4,2.7,;4,4.24,;2.67,1.93,;1.33,2.7,;1.33,4.24,;,5,;-1.33,4.24,;-1.33,2.7,;,1.93,;-2.67,5.01,;-4,4.23,;-4,2.69,;-5.33,1.92,;-6.67,2.69,;-8,1.92,;-6.67,4.23,;-5.33,5,;-5.33,.38,;-6.67,-.39,;-6.67,-1.93,;-5.33,-2.7,;-4,-1.93,;-2.67,-2.7,;-1.33,-1.93,;,-2.7,;,-4.24,;1.33,-5.01,;2.67,-4.24,;2.67,-2.7,;1.33,-1.93,;,-1.16,;,.38,;-4,-.39,)|
Structure:
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