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Target
RAC-alpha serine/threonine-protein kinase
Ligand
BDBM126594
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
pH
7.5±n/a
IC50
1.4±n/a nM
Comments
extracted
Citation
 Nakamura, M; Niiyama, K; Kamijo, K; Ohkubo, M; Shimomura, T Imidazo-oxazine compound or salt thereof US Patent  US8772283 Publication Date 7/8/2014 
Target
Name:
RAC-alpha serine/threonine-protein kinase
Synonyms:
AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)
Type:
Enzyme
Mol. Mass.:
55681.25
Organism:
Homo sapiens (Human)
Description:
P31749
Residue:
480
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
  
Inhibitor
Name:
BDBM126594
Synonyms:
US8772283, 38
Type:
Small organic molecule
Emp. Form.:
C28H26N4O2
Mol. Mass.:
450.5316
SMILES:
NC1(CC(O)(C1)C1CC1)c1ccc(cc1)-c1nc2-c3cccnc3OCn2c1-c1ccccc1 |(7.56,3.47,;6.23,4.24,;5.14,5.33,;6.31,6.43,;6.36,7.97,;7.32,5.33,;4.9,7.07,;3.57,6.3,;4.13,8.4,;4.89,3.47,;3.56,4.24,;2.23,3.47,;2.23,1.93,;3.56,1.16,;4.89,1.93,;.93,1.09,;-.5,1.64,;-1.47,.45,;-3.01,.45,;-3.78,1.78,;-5.32,1.78,;-6.09,.45,;-5.32,-.89,;-3.78,-.89,;-3.01,-2.22,;-1.47,-2.22,;-.7,-.89,;.85,-.45,;2.06,-1.41,;1.66,-2.89,;2.75,-3.98,;4.23,-3.58,;4.63,-2.1,;3.54,-1.01,)|
Structure:
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