Reaction Details Report a problem with these data
Target
Membrane metallo-endopeptidase-like 1
Ligand
BDBM130355
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
4±n/a nM
Comments
extracted
Citation
 Iwaki, Y; Karki, RG; Ksander, GM Substituted aminopropionic derivatives as neprilysin inhibitors US Patent  US8822534 Publication Date 9/2/2014 
Target
Name:
Membrane metallo-endopeptidase-like 1
Synonyms:
Endopeptidase (NEP) | MELL1 | MMEL1 | MMEL1_HUMAN | MMEL2 | NEP2 | Neutral endopeptidase (NEP)
Type:
Enzyme
Mol. Mass.:
89358.76
Organism:
Human
Description:
Q495T6
Residue:
779
Sequence:
MGKSEGPVGMVESAGRAGQKRPGFLEGGLLLLLLLVTAALVALGVLYADRRGKQLPRLASRLCFLQEERTFVKRKPRGIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW
  
Inhibitor
Name:
BDBM130355
Synonyms:
US8822534, Example 5-7 | US8993631, 5-3
Type:
Small organic molecule
Emp. Form.:
C21H23NO6
Mol. Mass.:
385.4104
SMILES:
COc1ccccc1-c1ccc(C[C@H](CC(O)=O)NC(=O)CCC(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: