Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM138151
Substrate
n/a
Meas. Tech.
Biological Assay
pH
6±n/a
IC50
>10000±n/a nM
Comments
extracted
Citation
 Chaplin, DJ; Gaddale Devanna, KK; Parker, E; Pinney, KG; Song, J; Trawick, ML Compositions and methods for inhibition of cathepsins US Patent  US8877967 Publication Date 11/4/2014 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM138151
Synonyms:
US8877967, 22
Type:
Small organic molecule
Emp. Form.:
C27H29N3O3S
Mol. Mass.:
475.602
SMILES:
CC(C)Oc1ccc(cc1)C(=O)c1cccc(c1)C(=NNC(N)=S)c1ccc(OC(C)C)cc1 |w:19.21|
Structure:
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