Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM140533
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Ki
6.5±n/a nM
Comments
extracted
Citation
 Aebi, J; Binggeli, A; Hertel, C; Konkar, AA; Kuehne, H; Kuhn, B; Maerki, HP; Wang, H Biaryl amide derivatives US Patent  US8912221 Publication Date 12/16/2014 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM140533
Synonyms:
US8912221, 6
Type:
Small organic molecule
Emp. Form.:
C22H19ClF4N2O5
Mol. Mass.:
502.843
SMILES:
COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(COC2)NC(=O)C(F)(F)F)c(F)c1 |r|
Structure:
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