Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM141357
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
0.5±n/a nM
Citation
 Hayashi, K; Tamura, Y; Omori, N 5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity US Patent  US8916594 Publication Date 12/23/2014 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_MOUSE | Neuropeptide Y receptor Y5 | Neuropeptide Y receptor type 5 (NPY Y5) | Npy5 | Npy5r
Type:
Enzyme
Mol. Mass.:
52807.91
Organism:
Mus musculus (Mouse)
Description:
O70342
Residue:
466
Sequence:
MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM141357
Synonyms:
US8916594, I-138
Type:
Small organic molecule
Emp. Form.:
C16H27FN4O3S
Mol. Mass.:
374.474
SMILES:
CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)C1(F)CCCC1 |r,wU:7.6,wD:10.13,(-9.14,.87,;-7.81,.1,;-6.47,.87,;-7.24,2.21,;-5.7,2.21,;-5.14,.1,;-3.81,.87,;-2.47,.1,;-1.14,.87,;.19,.1,;.19,-1.44,;-1.14,-2.21,;-2.47,-1.44,;1.53,-2.21,;2.86,-1.44,;4.33,-1.91,;5.23,-.67,;4.33,.58,;2.86,.1,;6.77,-.67,;6,.67,;7.68,-1.91,;9.14,-1.44,;9.14,.1,;7.68,.58,)|
Structure:
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