Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM141361
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
0.61±n/a nM
Citation
 Hayashi, K; Tamura, Y; Omori, N 5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity US Patent  US8916594 Publication Date 12/23/2014 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_MOUSE | Neuropeptide Y receptor Y5 | Neuropeptide Y receptor type 5 (NPY Y5) | Npy5 | Npy5r
Type:
Enzyme
Mol. Mass.:
52807.91
Organism:
Mus musculus (Mouse)
Description:
O70342
Residue:
466
Sequence:
MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM141361
Synonyms:
US8916594, I-147
Type:
Small organic molecule
Emp. Form.:
C17H28F2N4O3S
Mol. Mass.:
406.491
SMILES:
CC(C)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)C1(C)CC(F)(F)C1 |r,wU:8.7,wD:11.14,(-9.71,.87,;-8.38,.1,;-8.38,-1.44,;-7.04,.87,;-7.81,2.21,;-6.27,2.21,;-5.71,.1,;-4.38,.87,;-3.04,.1,;-1.71,.87,;-.38,.1,;-.38,-1.44,;-1.71,-2.21,;-3.04,-1.44,;.96,-2.21,;2.29,-1.44,;3.76,-1.91,;4.66,-.67,;3.76,.58,;2.29,.1,;6.2,-.67,;5.43,.67,;7.29,-1.76,;8.38,-.67,;9.71,.1,;9.71,-1.44,;7.29,.42,)|
Structure:
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