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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM143742
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Temperature
277.15±n/a K
Ki
74±n/a nM
Comments
extracted
Citation
 Gelin, CF; Lebold, TP; Shireman, BT Substituted 2-azabicycles and their use as orexin receptor modulators US Patent  US8969352 Publication Date 3/3/2015 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R
Type:
Protein
Mol. Mass.:
46817.55
Organism:
Rattus norvegicus (Rat)
Description:
P56718
Residue:
416
Sequence:
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
  
Inhibitor
Name:
BDBM143742
Synonyms:
US10183953, Example 1 | US8969352, 1 | US9611277, Example 1 | US9845333, 1
Type:
Small organic molecule
Emp. Form.:
C20H17F3N6O2
Mol. Mass.:
430.3832
SMILES:
FC(F)(F)c1cnc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)cn1 |TLB:16:14:9.10:12,THB:8:9:14.15:12|
Structure:
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