Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM148980
Substrate
n/a
Meas. Tech.
Competitive Displacement Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
0.66±n/a nM
Comments
extracted
Citation
 Blumberg, LC; Arnelle, D Peripherally acting opioid compounds US Patent  US8962646 Publication Date 2/24/2015 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM148980
Synonyms:
US8962646, 2
Type:
Small organic molecule
Emp. Form.:
C37H38N4O6
Mol. Mass.:
634.7208
SMILES:
Oc1c(ccc2C[C@H]3N(CCc4ccccc4)CC[C@@]4(CC(=O)CC[C@@]34O)c12)C(=O)NCCc1ccc(cc1)-c1c[nH]c(=O)[nH]c1=O |r|
Structure:
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