Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM150256
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
Ki
4.8±n/a nM
Comments
extracted
Citation
 Lambin, P; Winum, J; Supuran, C Cancer targeting using carbonic anhydrase isoform IX inhibitors US Patent  US8980932 Publication Date 3/17/2015 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM150256
Synonyms:
US8980932, 4c (DH305)
Type:
Small organic molecule
Emp. Form.:
C13H15N5O5S
Mol. Mass.:
353.354
SMILES:
NS(=O)(=O)c1ccc(CCNC(=O)Cn2ccnc2[N+]([O-])=O)cc1
Structure:
Search PDB for entries with ligand similarity: