Reaction Details Report a problem with these data
Target
Carbonic anhydrase 12
Ligand
BDBM150253
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
Ki
64±n/a nM
Comments
extracted
Citation
 Lambin, P; Winum, J; Supuran, C Cancer targeting using carbonic anhydrase isoform IX inhibitors US Patent  US8980932 Publication Date 3/17/2015 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM150253
Synonyms:
US8980932, 4a (DH296)
Type:
Small organic molecule
Emp. Form.:
C11H11N5O5S
Mol. Mass.:
325.301
SMILES:
NS(=O)(=O)c1ccc(NC(=O)Cn2ccnc2[N+]([O-])=O)cc1
Structure:
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