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Target
Cyclin-dependent kinase 2
Ligand
BDBM150753
Substrate
n/a
Meas. Tech.
Protein Kinase Assay
pH
7.5±n/a
Temperature
303.15±n/a K
Kd
3.25e+4± 6.7e+3 nM
Comments
extracted
Citation
 Hamdi, A; Lesnard, A; Suzanne, P; Robert, T; Miteva, MA; Pellerano, M; Didier, B; Ficko-Blean, E; Lobstein, A; Hibert, M; Rault, S; Morris, MC; Colas, P Tampering with cell division by using small-molecule inhibitors of CDK-CKS protein interactions. Chembiochem 16:432-9 (2015) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM150753
Synonyms:
4-hydrazino-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidine (A1)
Type:
Small organic molecule
Emp. Form.:
C11H14N4S
Mol. Mass.:
234.321
SMILES:
NNc1ncnc2sc3CCCCCc3c12
Structure:
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