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Target
Cyclin-dependent kinase 2
Ligand
BDBM150754
Substrate
n/a
Meas. Tech.
Protein Kinase Assay
pH
7.5±n/a
Temperature
303.15±n/a K
Kd
1.78e+4± 2.8e+3 nM
Comments
extracted
Citation
 Hamdi, A; Lesnard, A; Suzanne, P; Robert, T; Miteva, MA; Pellerano, M; Didier, B; Ficko-Blean, E; Lobstein, A; Hibert, M; Rault, S; Morris, MC; Colas, P Tampering with cell division by using small-molecule inhibitors of CDK-CKS protein interactions. Chembiochem 16:432-9 (2015) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM150754
Synonyms:
11-O-acetyl-aloe-emodin | 3-[(acetyloxy)methyl]-1,8-dihydroxy-anthracene-9,10-dione (B1)
Type:
Small organic molecule
Emp. Form.:
C17H12O6
Mol. Mass.:
312.2736
SMILES:
CC(=O)OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
Structure:
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