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Target
Protein-tyrosine kinase 2-beta
Ligand
BDBM286342
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Ki
11.1±n/a nM
Comments
extracted
Citation
 Li, H; Nukui, S; Scales, SA; Teng, M; Yin, C Substituted pyrrolo[3,4-c]pyrazoles as PKC kinase inhibitors US Patent  US9518060 Publication Date 12/13/2016 
Target
Name:
Protein-tyrosine kinase 2-beta
Synonyms:
FAK2 | FAK2_HUMAN | PTK2B | PTK2B protein tyrosine kinase 2 beta | PTK2B protein tyrosine kinase 2 beta (PTK2B) | PYK2 | Protein tyrosine kinase 2 beta | RAFTK
Type:
Protein
Mol. Mass.:
115868.80
Organism:
Homo sapiens (Human)
Description:
Q14289
Residue:
1009
Sequence:
MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMREEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
  
Inhibitor
Name:
BDBM286342
Synonyms:
US11220518, Ex. No. J16 | US11780853, Example J16 | US9518060, Example J16
Type:
Small organic molecule
Emp. Form.:
C26H40N8O2
Mol. Mass.:
496.6482
SMILES:
C[C@@H]1CN([C@@H](C)CN1CC1CCOCC1)C(=O)N1Cc2c(Nc3nc(C)cc(C)n3)n[nH]c2C1(C)C |r|
Structure:
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