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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM151977
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.02±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM151977
Synonyms:
US8987457, 171
Type:
Small organic molecule
Emp. Form.:
C31H32F3N7O3
Mol. Mass.:
607.6261
SMILES:
C[C@H]1C[C@H](C[C@@H](N)[C@H]1n1ccnn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCOCC2)cc1F |r,wU:3.14,1.0,5.5,7.8,(-1.33,.38,;-2.67,-.38,;-2.67,-1.93,;-4,-2.69,;-5.33,-1.93,;-5.33,-.38,;-6.67,.38,;-4,.38,;-4,1.93,;-5.25,2.83,;-4.77,4.29,;-3.23,4.29,;-2.76,2.83,;-4,-4.23,;-5.33,-5,;-5.33,-6.54,;-4,-7.31,;-2.67,-6.54,;-2.67,-5,;-1.33,-4.23,;,-5,;,-6.54,;1.33,-4.23,;2.67,-5,;4,-4.23,;4,-2.69,;5.33,-1.92,;2.67,-1.93,;1.33,-2.69,;2.67,-.38,;1.33,.38,;,-.38,;1.33,1.93,;2.67,2.69,;2.67,4.23,;4,5,;5.33,4.24,;6.67,5,;6.67,6.54,;5.33,7.31,;4,6.54,;4,1.93,;4,.38,;5.33,-.38,)|
Structure:
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