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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM151887
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
0.74±n/a nM
Citation
 Burger, M; Drumm, III, JE; Nishiguchi, G; Rico, A; Simmons, RL; Taft, B; Tanner, H Ring-substituted N-pyridinyl amides as kinase inhibitors US Patent  US8987457 Publication Date 3/24/2015 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM151887
Synonyms:
US8987457, 81
Type:
Small organic molecule
Emp. Form.:
C25H25F3N6O3
Mol. Mass.:
514.4996
SMILES:
COC(=O)N[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:11.12,6.6,5.4,(-6.67,4.23,;-5.33,3.47,;-4,4.23,;-4,5.78,;-2.67,3.47,;-2.67,1.93,;-1.33,1.16,;,1.93,;-1.33,-.38,;-2.67,-1.15,;-4,-.38,;-4,1.16,;-5.33,1.93,;-2.67,-2.69,;-4,-3.47,;-4,-5,;-2.67,-5.78,;-1.33,-5,;-1.33,-3.47,;,-2.69,;1.33,-3.47,;1.33,-5,;2.67,-2.69,;4,-3.46,;5.33,-2.69,;5.33,-1.15,;6.67,-.38,;4,-.38,;2.67,-1.15,;4,1.15,;2.67,1.93,;1.33,1.15,;2.67,3.47,;4,4.23,;5.33,3.47,;5.33,1.93,;6.67,1.15,)|
Structure:
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