Reaction Details Report a problem with these data
Target
C-terminal-binding protein 1
Ligand
BDBM154570
Substrate
n/a
Meas. Tech.
CtBP2 ITC
pH
8.5±0
Kd
2.77e+3± 3.4e+2 nM
Citation
 Hilbert, BJ; Morris, BL; Ellis, KC; Paulsen, JL; Schiffer, CA; Grossman, SR; Royer, WE Structure-guided design of a high affinity inhibitor to human CtBP. ACS Chem Biol 10:1118-27 (2015) [PubMed]  Article 
Target
Name:
C-terminal-binding protein 1
Synonyms:
C-terminal binding protein (CtBP1) | C-terminal-binding protein 1 (CtBP1) | CTBP | CTBP1 | CTBP1_HUMAN
Type:
Protein
Mol. Mass.:
47537.80
Organism:
Homo sapiens (Human)
Description:
Q13363
Residue:
440
Sequence:
MGSSHLLNKGLPLGVRPPIMNGPLHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYRYPPGVVGVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHASDQL
  
Inhibitor
Name:
BDBM154570
Synonyms:
2-Hydroxyimino-3-phenylpropanoic acid (HIPP)
Type:
Small organic molecule
Emp. Form.:
C9H9NO3
Mol. Mass.:
179.1727
SMILES:
ON=C(Cc1ccccc1)C(O)=O |w:1.0|
Structure:
Search PDB for entries with ligand similarity: