Reaction Details Report a problem with these data
Target
AMP deaminase 1
Ligand
BDBM154583
Substrate
n/a
Meas. Tech.
AMPD Enzymatic Activity Assay
pH
7.4±n/a
IC50
38±n/a nM
Comments
extracted
Citation
 Admyre, T; Amrot-Fors, L; Andersson, M; Bauer, M; Bjursell, M; Drmota, T; Hallen, S; Hartleib-Geschwindner, J; Lindmark, B; Liu, J; Löfgren, L; Rohman, M; Selmi, N; Wallenius, K Inhibition of AMP deaminase activity does not improve glucose control in rodent models of insulin resistance or diabetes. Chem Biol 21:1486-96 (2014) [PubMed]  Article 
Target
Name:
AMP deaminase 1
Synonyms:
AMP deaminase 1 (hAMPD1) | AMP deaminase isoform M | AMPD1 | AMPD1_HUMAN | Myoadenylate deaminase
Type:
Protein
Mol. Mass.:
90225.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
780
Sequence:
MNVRIFYSVSQSPHSLLSLLFYCAILESRISATMPLFKLPAEEKQIDDAMRNFAEKVFASEVKDEGGRQEISPFDVDEICPISHHEMQAHIFHLETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQITGDYASGVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESFYPVFTPPVKKGEDPFRTDNLPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTFLDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPSYTYYAYYMYANIMVLNSLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNVAQIRMAYRYETWCYELNLIAEGLKSTE
  
Inhibitor
Name:
BDBM154583
Synonyms:
6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methyl)phenyl]pyridine-3-carboxylic acid (Compound 3)
Type:
Small organic molecule
Emp. Form.:
C24H21N3O2
Mol. Mass.:
383.4424
SMILES:
C[C@H](NCc1ccc(cc1)-c1ccc(cn1)C(O)=O)c1cccc2ccncc12 |r|
Structure:
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